Genotype-Guided Warfarin Therapy Trial
Completed · Not applicable
Conditions studied: Atrial Fibrillation, Deep Vein Thrombosis, Pulmonary Embolism, Artificial Heart Valve
In brief
The purpose of the investigators' study is to determine the clinical utility of a warfarin-dosing algorithm that incorporates genetic information (VKORC1 and CYP2C9 alleles) for adult patients initiating warfarin therapy.
Key facts
- Study ID
- NCT00904293
- Run by
- University of North Carolina, Chapel Hill
- People needed
- 109
- Starts
- 2008-08-01
- Expected to finish
- 2012-01-01
- Last updated by the study team
- 2016-05-06
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adults ≥18 years old
- Patients who are beginning warfarin for a variety of diseases or conditions that require long-term oral anticoagulation with target INR > 2.0 for at least 3 months
- Subjects that will be following up in UNC anticoagulation clinics at the Ambulatory Care Center or the Family Medicine Center
You may not qualify if…
- Patients who are unable to complete the study materials (questionnaires) with or without assistance (for example, those with dementia)
- Non-English speaking patients
- Patients who are being started on anticoagulation intended to last < 3 months or whose target INR is < 2.0
- Patients who have a history of treatment with warfarin and a known dose requirement will be excluded (as they should be restarted on the previous dose)
- Pregnant women will be excluded because warfarin is a teratogen and pregnant women should not take the medication
- Patients will also be excluded if their treating physician does not agree to use the recommended INR dose or feels that the patient should not be enrolled in the study
Where it is running
- UNC Hospitals, UNC Anticoagulation Clinic at the Ambulatory Care Center (ACC), UNC Family Medicine Center Anti-coagulation Clinic — Chapel Hill, North Carolina, United States
Full record on ClinicalTrials.gov
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