Mucus Dehydration and Evolution of Chronic Obstructive Pulmonary Disease (COPD) Lung Disease

Completed

Conditions studied: Chronic Obstructive Pulmonary Disease, Chronic Bronchitis

In brief

The purpose of this research is to understand the properties of mucus in persons with COPD, specifically Chronic Bronchitis. We hypothesize that those with Chronic Bronchitis have dehydrated mucus, and thus have a harder time coughing it out of their lungs. This leads to a greater vulnerability for lung infection, inflammation and airflow obstruction. Ultimately, our goal is to understand how mucus dehydration contributes to the progression of COPD/Chronic Bronchitis so that better therapies and interventions can be developed for future generations.

Key facts

Study ID

NCT00903955

Run by

University of North Carolina, Chapel Hill

People needed

100

Starts

2006-09-01

Expected to finish

2012-03-01

Last updated by the study team

2013-02-07

Who can join

Age: 18 and older, up to 82. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• history of COPD/chronic bronchitis defined as having a productive cough for three months of the year for at least two successive years
• greater than or equal to a 10 pack year cigarette smoking history
• ability to perform spirometry

You may not qualify if…

• unstable lung disease
• allergy to study medications
• radiation exposure within past year exceeding Federal Regulation Limits

Where it is running

• University of North Carolina Chapel Hill — Chapel Hill, North Carolina, United States

Full record on ClinicalTrials.gov

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