Impact of Vitamin D Supplementation on Lactation Associated Bone Loss

Completed · Not applicable

Conditions studied: Osteoporosis

In brief

Studies have shown that lactation is associated with a loss of bone density from four to seven percent at the spine and hip among women who lactate for six months. Decline in bone density with lactation occurs rapidly. Although bone density increases after weaning, there is controversy on whether or not it is completely restored. Epidemiological studies find no significant negative impact of lactation on bone mass or fractures, and in fact there is evidence that lactation has a positive effect on bone mass. We think that interventions that attenuate this physiologic loss of bone that is associated with lactation and accelerate restoration of bone mass after weaning may result in improved long term bone mass and diminished fracture risk.

Key facts

Study ID

NCT00903344

Run by

Leigh Eck, MD

People needed

22

Starts

2009-12-01

Expected to finish

2012-06-01

Last updated by the study team

2014-08-18

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Fully lactating mothers age 18 and up
• Within 1 month after delivery
• Plan to breast feed for at least 6 months

You may not qualify if…

• Known metabolic bone disease
• Chronic renal insufficiency
• Chronic corticosteroid use
• Eating disorder
• Estrogen containing hormonal contraception use
• Daily use of >400IU Vitamin D supplementation
• Delivery of Multiples
• Delivery of a singleton with a birth weight of <2500 grams
• Preterm delivery of baby
• History of kidney stones

Where it is running

• University of Kansas Medical Center — Kansas City, Missouri, United States

Full record on ClinicalTrials.gov

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