Evolution of Memory Related Activity

Status unconfirmed

Conditions studied: Alzheimer's Disease, Mild Cognitive Impairment

In brief

The purpose of this study is to begin the process of validating fMRI (functional magnetic resonance imaging) as a biomarker for use in clinical trials and longitudinal studies of clinical progression in mild cognitive impairment (MCI) and Alzheimer's disease (AD).

Key facts

Study ID

NCT00902499

Run by

National Institute on Aging (NIA)

People needed

160

Starts

2006-05-01

Expected to finish

2011-05-01

Last updated by the study team

2010-07-26

Who can join

Age: 55 and older, up to 90. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Ages 55-90
• General good health or stable medical problems
• Study partner/caregiver able to provide an independent evaluation of the participant's daily functioning
• No contraindications to MR scanning
• Modified Hachinski Ischemic Score ≤4
• Geriatric Depression Scale ≤10

You may not qualify if…

• Diagnosis of Parkinson's disease or other neurological illness
• Presence of clinically significant/uncontrolled medical conditions
• History of stroke, brain tumor, brain surgery, seizures, significant head trauma with loss of consciousness, depression or other psychiatric illness, alcohol or drug abuse in the past 2 years
• Significant uncorrectable visual impairment

Where it is running

• Brigham and Women's Hospital — Boston, Massachusetts, United States (enrolling)
• Massachusetts General Hospital — Boston, Massachusetts, United States (enrolling)

Full record on ClinicalTrials.gov

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