Vitamin B12 and Folate Administration on Homocysteine Concentrations After Nitrous Oxide Anesthesia

Completed · Not applicable · Has a placebo group

Conditions studied: Cardiovascular Abnormalities

In brief

The goal of this study is to find out if giving intravenous B-vitamins before general anesthesia with nitrous oxide prevents the increase in homocysteine, a metabolite that has been linked to cardiovascular complications.

Key facts

Study ID

NCT00901394

Run by

Washington University School of Medicine

People needed

63

Starts

2009-03-01

Expected to finish

2010-01-01

Last updated by the study team

2020-09-16

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients scheduled for elective surgery with expected duration > 2 hours
• Healthy patients undergoing moderate surgery where the use of N2O is unproblematic

You may not qualify if…

• Contraindication against N2O (pneumothorax, mechanical bowel obstruction, middle ear occlusion, laparoscopic surgery, raised intracranial pressure)
• Patients requiring supplemental oxygen
• Urgent or emergent surgery
• Patients with vitamin B12 or folate deficiency or megaloblastic anemia
• Patients with seizure disorder (epilepsy)
• Allergy or hypersensitivity against IV cobalamin or folate
• Patients with Leber's disease (hereditary optic nerve atrophy)
• Patients taking supplemental vitamin B12 or folate

Where it is running

• Barnes Jewish Hospital — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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