Pilot Study of Abbreviated Chemotherapy Based on Positron Emission Tomography (PET) Scan in Hodgkin's Lymphoma

Stopped early · Not applicable

Conditions studied: Hodgkin's Lymphoma

In brief

The primary objective of the study is to determine the progression-free survival \[PFS\] at 36 months for patients with Hodgkin lymphoma who achieve a complete metabolic response as demonstrated by a negative fluorodeoxyglucose (FDG)-PET scan after one cycle of ABVD (adriamycin, bleomycin, vinblastine, dacarbazine) who undergo abbreviated ABVD chemotherapy (3 cycles).

Key facts

Study ID

NCT00901303

Run by

Weill Medical College of Cornell University

People needed

6

Starts

2008-10-01

Expected to finish

2011-05-23

Last updated by the study team

2018-08-31

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Histologically documented classical Hodgkin lymphoma according to the WHO Classification. Nodular lymphocyte predominant Hodgkin lymphoma is excluded
• No prior treatment (chemotherapy or radiation therapy) for Hodgkin lymphoma
• Measurable disease must be present either on physical examination or imaging studies. Any tumor mass measurable in two dimensions and > 2 cm is acceptable (or 1.5 cm if 0.5 cm slices are used as in spiral CT scans)
• Age ≥ 18
• Patients must have at least one hypermetabolic lesion identifiable on initial PET scan
• LVEF by ECHO or MUGA within institutional normal limits
• Initial laboratory data should be compatible with the administration of standard doses of ABVD chemotherapy

You may not qualify if…

• Patient has no known HIV infection
• Patient is non-pregnant and non-lactating. Due to the teratogenic potential of the agents used in this study, pregnant or nursing women may not be enrolled. Women and men of reproductive potential should agree to use an effective means of birth control
• No other history of lymphoproliferative disorder or granulomatous disease

Where it is running

• Weill Cornell Medical College — New York, New York, United States

Full record on ClinicalTrials.gov

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