Intra-arterial Chemotherapy(Chemosurgery) for Retinoblastoma

Completed · Phase 1/Phase 2

Conditions studied: Retinoblastoma

In brief

Conventional treatments of retinoblastoma involves laser photocoagulation, cryotherapy (freezing of the tumor), plaque radiotherapy,external beam radiotherapy, and intravenous chemotherapy. Enucleation (removing of the eye)is the last option when the tumor cannot be controlled otherwise. However,many children with retinoblastoma present with advanced intraocular disease for which enucleation is the only option. Intra-arterial chemotherapy (Chemosurgery)delivers anti-tumor drug directly into the ophthalmic artery (the artery feeding the eye) in order to increase the dose of drug reaching the tumor while minimizing toxicity to the rest of the body.

Key facts

Study ID

NCT00901238

Run by

Weill Medical College of Cornell University

People needed

100

Starts

2006-05-01

Expected to finish

2009-07-01

Last updated by the study team

2009-12-17

Who can join

Age: 0 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• advanced retinoblastoma in one or both eyes
• recurrent retinoblastoma after failure of conventional methods

You may not qualify if…

• retinoblastoma judged curable by conventional methods
• patient judged unable to undergo the procedure

Where it is running

• Memorial Sloan Kettering Cancer Center — New York, New York, United States
• Weill Medical College of Cornell University — New York, New York, United States

Full record on ClinicalTrials.gov

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