Implications of Amyloid Pathology

Status unconfirmed

Conditions studied: Alzheimer's Disease

In brief

The purpose of this study is to determine whether asymptomatic older individuals with high amyloid burden will subsequently manifest cognitive impairment and eventually progress to clinical Alzheimer's Disease (AD).

Key facts

Study ID

NCT00900770

Run by

National Institute on Aging (NIA)

People needed

100

Starts

2008-11-01

Expected to finish

2014-03-01

Last updated by the study team

2009-12-29

Who can join

Age: 60 and older, up to 90. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age range from 60 to 90 years
• Clinical Dementia Rating (CDR) Score of 0
• Mini Mental State Exam of 27-30
• A study partner who can answer questions pertaining to daily functioning
• Perform within 1.5 standard deviation of age and education matched norms on screening tests of attention and executive function, language, visuospatial perception and episodic memory
• Stable medications for at least 30 days
• Fluent in English
• Modified Hachinski Score of <4
• Geriatric Depression Scale Score <10

You may not qualify if…

• Diagnosis of MCI or dementia
• Individuals with contraindications to MRI (i.e., implanted metal including pacemakers, cerebral spinal fluid shunts, aneurysm clips, artificial heart valves, ear implants or metal/foreign objects in the eyes and those with a history of claustrophobia)
• Unstable medications or on medications with CNS effects including cholinesterase inhibitors, memantine, and antidepressants
• Major psychiatric disorders such as schizophrenia, schizoaffective disorder, major affective disorder, or treatment with ECT (mild depression that is well treated with stable dose of SSRI antidepressants will be allowed)
• Multiple sclerosis or other autoimmune disorders
• Huntington's disease
• Head injury, post-traumatic dementia or seizures
• Metabolic encephalopathy, CNS infection, hydrocephalus
• Cardiovascular disease, stroke, congestive heart failure
• Substance abuse within the past 2 years
• Active cancer
• Active hematological, renal, pulmonary, endocrine or hepatic disorders

Where it is running

• Brigham and Women's Hospital — Boston, Massachusetts, United States (enrolling)

Full record on ClinicalTrials.gov

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