DNA Analysis of Tumor Tissue Samples From Patients With Diffuse Brain Stem Glioma
Completed
Conditions studied: Brain Tumors, Central Nervous System Tumors
In brief
This multi-institutional study will prospectively collect tumor and constitutional tissue samples from patients with diffuse brainstem glioma and other types of brainstem gliomas either during therapy or at autopsy to perform an extensive analysis of genetic and molecular abnormalities in these tumors.
Key facts
- Study ID
- NCT00899834
- Run by
- St. Jude Children's Research Hospital
- People needed
- 81
- Starts
- 2006-06-01
- Expected to finish
- 2015-08-01
- Last updated by the study team
- 2016-07-26
Who can join
Age: any, up to 18. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients of any age with clinical and radiologic diagnosis of diffuse brainstem glioma
- Patients with other high-grade gliomas originating in the brainstem
- Patients with focal gliomas (WHO grade I/II) of the brainstem
- Enrollment in the current version of the St. Jude Tissue Bank protocol for patients whose tissue samples were obtained at diagnosis and who received treatment at St. Jude Children's Research Hospital (SJCRH), or correspondent tissue banking consent for patients treated in other institutions if tissue was obtained prior to death (as applicable, depending on the standard of each institution)
You may not qualify if…
- Patients with any type of infiltrative low-grade (WHO grade II) or high-grade glioma (WHO grade III and IV) originating outside the brainstem
- Patients harboring primary brainstem tumors with other histologic diagnoses (e.g., PNET)
Where it is running
- Stanford University Medical Center — Palo Alto, California, United States
- St. Jude Children's Research Hospital — Memphis, Tennessee, United States
- Seattle Children's Hospital — Seattle, Washington, United States
Full record on ClinicalTrials.gov
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