Collecting and Storing Tissue From Young Patients With Cancer

Completed

Conditions studied: Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Central Nervous System Neoplasm, Ewing Sarcoma, Germ Cell Tumor, Leukemia, Lymphoma, Malignant Neoplasm, Neuroblastoma, Osteosarcoma, Retinoblastoma, Rhabdoid Tumor, Rhabdomyosarcoma, Soft Tissue Sarcoma

In brief

This laboratory study is collecting and storing tissue, blood, and bone marrow samples from young patients with cancer. Collecting and storing samples of tissue, blood, and bone marrow from patients with cancer to study in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer.

Key facts

Study ID

NCT00898755

Run by

Children's Oncology Group

People needed

213

Starts

2007-03-05

Expected to finish

2025-03-31

Last updated by the study team

2025-05-02

Who can join

Age: any, up to 21. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• All malignant tissues from childhood cancers allowed including the following:
• Brain tumors (all types)
• Tissue should be submitted to CNS Committee Resource labs to be forwarded for this study, unless instructed otherwise on the COG web site
• Ewing family of tumors
• Rhabdomyosarcomas
• Other soft tissue sarcomas
• Osteogenic sarcomas
• Rhabdoid tumors
• Neuroblastomas
• Viable material for cell culture for neuroblastoma is collected via COG-ANBL00B1 and should not be submitted via this study unless the patient cannot be enrolled on COG-ANBL00B1*
• Retinoblastomas
• Anaplastic Wilms tumor
• Germ cell tumors
• Leukemias/lymphomas
• Acute myeloid leukemia (AML)
• Blood samples and bone marrow samples from patients at second relapse and beyond may be submitted for this study
• Bone marrow samples at diagnosis or first relapse must be submitted to an AML resource lab and will be forwarded for this study at the discretion of the AML Committee
• Acute lymphoblastic leukemia (ALL)
• Blood samples may be submitted directly to this study
• Bone marrow samples must be submitted to an ALL resource lab and will be forwarded for this study at the discretion of the ALL Committee
• Enrolled on a COG therapeutic, biology, or tissue banking protocol that allows collection of tissue for research and submission to a COG-designated resource laboratory
• Participation in this protocol is not permitted until after tissue requirements for any active COG disease-specific therapeutic, biology, or banking protocols have been satisfied
• Material may only be submitted for this protocol if tissue is available in excess of that required for satisfying active disease-specific therapeutic and biological protocols
• Patients with diagnosis pending are eligible

Where it is running

• University of Alabama at Birmingham Cancer Center — Birmingham, Alabama, United States
• Arkansas Children's Hospital — Little Rock, Arkansas, United States
• University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
• Kaiser Permanente Downey Medical Center — Downey, California, United States
• City of Hope Comprehensive Cancer Center — Duarte, California, United States
• Miller Children's and Women's Hospital Long Beach — Long Beach, California, United States
• Children's Hospital Los Angeles — Los Angeles, California, United States
• Children's Hospital and Research Center at Oakland — Oakland, California, United States
• Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center — Denver, Colorado, United States
• Connecticut Children's Medical Center — Hartford, Connecticut, United States
• MedStar Georgetown University Hospital — Washington D.C., District of Columbia, United States
• Lee Memorial Health System — Fort Myers, Florida, United States
• Golisano Children's Hospital of Southwest Florida — Fort Myers, Florida, United States
• Johns Hopkins All Children's Hospital — St. Petersburg, Florida, United States
• Tampa General Hospital — Tampa, Florida, United States
• Saint Joseph's Hospital/Children's Hospital-Tampa — Tampa, Florida, United States
• Saint Mary's Hospital — West Palm Beach, Florida, United States
• Saint Luke's Mountain States Tumor Institute — Boise, Idaho, United States
• University of Illinois — Chicago, Illinois, United States
• Saint Jude Midwest Affiliate — Peoria, Illinois, United States
• Southern Illinois University School of Medicine — Springfield, Illinois, United States
• University of Kentucky/Markey Cancer Center — Lexington, Kentucky, United States
• Norton Children's Hospital — Louisville, Kentucky, United States
• Tulane University Health Sciences Center — New Orleans, Louisiana, United States
• Children's Hospital of Alabama — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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