Response or Resistance to Chemotherapy in Young Patients With Acute Lymphoblastic Leukemia Treated With Methotrexate

Completed

Conditions studied: B-cell Childhood Acute Lymphoblastic Leukemia, Childhood Acute Lymphoblastic Leukemia in Remission, Recurrent Childhood Acute Lymphoblastic Leukemia, T-cell Childhood Acute Lymphoblastic Leukemia

In brief

This laboratory study is looking at response or resistance to chemotherapy in young patients with acute lymphoblastic leukemia treated with methotrexate. Studying samples of tumor tissue in the laboratory from patients with cancer may help doctors learn more about changes that occur in DNA and drug resistance in patients.

Key facts

Study ID

NCT00898404

Run by

Children's Oncology Group

People needed

150

Starts

2003-11-01

Expected to finish

2016-05-01

Last updated by the study team

2016-05-11

Who can join

Age: any, up to 17. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of B-precursor or T-cell acute lymphoblastic leukemia
• Newly diagnosed disease subsequently treated with methotrexate
• Banked diagnostic blast specimens are available from Childrens Oncology Group (COG) cellbank

Where it is running

• Children's Oncology Group — Arcadia, California, United States

Full record on ClinicalTrials.gov

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