Functional MRI Before and After Treatment for Depression

Stopped early · Not applicable

Conditions studied: Depression, Mood Disorders, Depressive Disorder

In brief

The purpose of this study is to help us understand how depression changes brain activity and how this relates to mood, anxiety, and cognitive functions like memory. We also hope to develop a brain imaging test that will predict either before or within two weeks of starting a medicine whether the treatment will work.

Key facts

Study ID

NCT00896441

Run by

Stanford University

People needed

31

Starts

2009-02-01

Expected to finish

2014-06-01

Last updated by the study team

2017-10-13

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patients will be aged 18-65, have no significant neurologic history, must meet DSM-IV criteria for a diagnosis of major depression and be free of antidepressant or other psychotropic medication for a minimum of two weeks before enrollment. If a subject is talking psychiatric medication he/she may be weaned off of the medication by their treating physician prior to study enrollment. Such a course of action would only be advised if the current medication was not considered to be of any benefit to the subject. In particular, if a patient is on antidepressant medication which is of benefit, we would not advise tapering off medication -- and subsequent risk of relapse -- in order to participate in the study. The same line of thinking applies to all psychiatric diagnoses and associated medications candidate subjects may be taking.

You may not qualify if…

• Significant head trauma with loss of consciousness.
• Active abuse of alcohol or illegal substances.
• Excluded psychiatric diagnoses include: Bipolar Affective Disorder, primary psychotic disorders (Schizophrenia, Schizoaffective disorder), Obsessive-Compulsive Disorder
• Pregnant or nursing women.
• Any contraindication to being scanned in the 3T scanner at the Lucas Center such as having a pacemaker or any implanted device that has not been cleared for scanning at 3 Tesla.
• Any significant neurologic history (i.e. seizure, stroke, multiple sclerosis).
• Use of psychotropic medications within 2 weeks of enrollment.

Where it is running

• Stanford University School of Medicine — Stanford, California, United States

Full record on ClinicalTrials.gov

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