Salt Loading and Thiazide Intervention Study

Completed · Phase 4

Conditions studied: Hypertension

In brief

The investigators of this study propose to examine the relationships between STK39 (Serine Threonine Kinase 39) genotypes and responses to salt loading and to thiazide diuretics, hydrochlorothiazide. The investigators hypothesize that STK39 genotypes will be associated with the outcome of both interventions and can contribute to personalized care for hypertension.

Key facts

Study ID

NCT00896389

Run by

University of Maryland, Baltimore

People needed

124

Starts

2009-10-01

Expected to finish

2013-03-01

Last updated by the study team

2022-03-25

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Old Order Amish
• Age 18 to 65
• Have systolic blood pressure between 120 and 160 and diastolic blood pressure between 80 and 100

You may not qualify if…

• History of myocardial infarction, stroke, congestive heart failure, liver disease
• Known cause of secondary hypertension
• Diabetes or Fasting glucose > 100 mg/dL
• Women who are pregnant, on oral contraceptives, or menstruating
• Used hydrochlorothiazide (HCTZ) in the last 8 weeks or known allergy to HCTZ
• Taking non-steroidal anti-inflammatory drugs
• Estimated glomerular filtration rate < 80 mL/m
• Intention to alter dietary habit during the study
• Abuse of alcohol or drug

Where it is running

• Amish Research Clinics — Lancaster, Pennsylvania, United States

Full record on ClinicalTrials.gov

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