The First Therapeutic Intervention in Malignant Pleural Effusion Trial

Completed · Not applicable

Conditions studied: Malignant Pleural Effusion, Pleural Effusion

In brief

Fluid caused by cancer cells may accumulate in the lining of the lung. Draining the fluid with a chest tube may relieve pain and shortness of breath. To stop the fluid from coming back again, patients are given a medicine (talc) into the chest drain to seal up the space around the lung. This procedure is known as pleurodesis. This sometimes causes pain and discomfort, and the investigators do not know the best way of preventing this. The investigators hope to find the best way to prevent pain during pleurodesis.

Key facts

Study ID

NCT00896285

Run by

University of California, Davis

People needed

4

Starts

2009-04-01

Expected to finish

2014-12-01

Last updated by the study team

2015-07-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Clinically confident diagnosis of malignant pleural effusion requiring pleurodesis. The diagnosis may be established by one of:
• Histologically proven pleural malignancy OR
• Typical features of pleural malignancy seen on direct vision during thoracoscopy OR
• Pleural effusion in the context of histologically proven cancer elsewhere
• Expected survival more than 1 month
• Written informed consent

You may not qualify if…

• Age < 18 years
• Primary lymphoma or small cell lung carcinoma
• Patients who are pregnant or lactating
• Inability to give informed consent
• History of GI bleeding or of untreated peptic ulceration
• Known sensitivity to non-steroidal anti-inflammatory drugs (NSAIDs)/opiates/acetaminophen
• Hypercapnic respiratory failure
• Known intravenous drug abuse
• Severe renal or liver disease
• Known bleeding diathesis
• Warfarin therapy
• Current or recent (within 2 weeks) corticosteroid steroid therapy

Where it is running

• UC Davis Medical Center — Sacramento, California, United States

Full record on ClinicalTrials.gov

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