Combination of Peripheral Nerve Block and DepoDur in Total Knee Joint Replacement
Stopped early · Phase 4
Conditions studied: Arthroplasty, Replacement, Knee
In brief
The investigators hypothesize that patients who receive a femoral catheter with low dose epidural Depodur will experience comparable or superior pain relief than those who receive both femoral and sciatic catheters. In addition, the investigators hypothesize that the one catheter will be less time consuming to place and facilitate early ambulation of the patient.
Key facts
- Study ID
- NCT00895531
- Run by
- University of Louisville
- People needed
- 75
- Starts
- 2009-12-01
- Expected to finish
- 2012-12-01
- Last updated by the study team
- 2017-07-27
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Scheduled for total knee replacement or revision of total knee replacement
- Agree to have a regional technique including neuraxial analgesia for post-operative analgesia
- Be 18 to 70 years old
- Classified as ASA score I-III
You may not qualify if…
- Allergic to morphine
- Allergic to local anesthetics
- Been on opioids for more than 4 weeks
- Not willing to be randomized
- On anticoagulation medications that prevent placement of epidural
- Sensitive to effects of neuraxial opioids
- BMI>35
- Severe COPD
- Obstructive sleep apnea (OSA, see below). Each patient will be asked the questions below to determine their risk for OSA (STOP questionnaire). Patients who answer yes to 3 or more of the major criteria of the STOP questionnaire and have one of the minor criteria will be excluded from the study
- STOP Questionnaire for OSA
- Major Criteria:
- S- Do you snore loudly (louder than talking or loud enough to be heard through closed doors)?
- T-"Do you often feel tired, fatigued, or sleepy during daytime?
- O-"Has anyone observed you stop breathing during your sleep?
- P-"Do you have or are you being treated for high blood pressure?
- Minor Criteria:
- BMI>35
- Age>50 yrs
- Neck Circumference>40 cm
- Male gender
Where it is running
- University of Louisville Hospital — Louisville, Kentucky, United States
Full record on ClinicalTrials.gov
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