MsFLASH-01: Escitalopram for Menopausal Symptoms in Midlife Women

Completed · Not applicable · Has a placebo group

Conditions studied: Hot Flashes, Menopause, Vasomotor Symptoms

In brief

The purpose of this study is to test whether a medication reduces the number, severity and bothersomeness of menopausal hot flashes. Escitalopram (also called Lexapro®) is a selective serotonin reuptake inhibitor (SSRI). It is sold by prescription for depression and general anxiety disorder. An SSRI increases serotonin, a brain substance that is believed to influence mood. Serotonin may also affect brain levels of estradiol, a hormone related to hot flashes. This research study will test whether escitalopram reduces menopausal hot flashes.

Key facts

Study ID

NCT00894543

Run by

Fred Hutchinson Cancer Center

People needed

205

Starts

2009-07-01

Expected to finish

2010-06-01

Last updated by the study team

2013-03-08

Who can join

Age: 40 and older, up to 62. Sex: female. Healthy volunteers: accepted.

Where it is running

• Northern California Kaiser, Division of Research — Oakland, California, United States
• Indiana University — Indianapolis, Indiana, United States
• Massachusetts General Hospital, Harvard Medical School — Boston, Massachusetts, United States
• Brigham and Women's Hospital — Chestnut Hill, Massachusetts, United States
• University of Pennsylvania — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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