The Effects of Azithromycin Ophthalmic Solution, 1% Versus Placebo in Subjects With Blepharitis During a Four-Week Treatment Period (P08638)

Completed · Phase 2 · Has a placebo group

Conditions studied: Blepharitis

In brief

The objective of this study is to compare the safety and efficacy of azithromycin ophthalmic solution, 1% versus placebo over a four-week treatment period.

Key facts

Study ID

NCT00894530

Run by

Merck Sharp & Dohme LLC

People needed

314

Starts

2009-05-01

Expected to finish

2009-12-01

Last updated by the study team

2013-11-21

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Have best corrected visual acuity in both eyes of at least +0.7 or better
• If female, are non-pregnant or non-lactating
• Have a current diagnosis of blepharitis in one or both eyes

You may not qualify if…

• Have lid structural abnormalities
• Have suspected ocular fungal or viral infection
• Have practiced warm compress therapy within 14 days prior to Visit 2
• Unable to withhold the use of contact lenses during the treatment or follow-up periods
• Unable to withhold the use of ocular cosmetic products within 24 hours prior to study visits
• Have had penetrating intraocular surgery within 90 days prior to Visit 2
• Have had ocular surface surgery within the past year prior to Visit 2
• Have a serious medical condition which could confound study assessments

Where it is running

• Schwartz Laser Eye Center — Scottsdale, Arizona, United States
• McDonald Eye Associates — Fayetteville, Arkansas, United States
• Sall Research Medical Center, Inc. — Artesia, California, United States
• Sall Research Medical Center — Artesia, California, United States
• United Medical Research Company — Inglewood, California, United States
• North Valley Eye Medical Group — Mission Hills, California, United States
• Coastal Vision Medical Group — Newport Beach, California, United States
• West Coast Eye Care — San Diego, California, United States
• Hernando Eye Institute — Brooksville, Florida, United States
• Center for Excellence in Eye Care — Miami, Florida, United States
• Wohl Eye Center — Bloomingdale, Illinois, United States
• Thomas John Vision Institute — Tinley Park, Illinois, United States
• Grene Vision Group — Wichita, Kansas, United States
• Taustine Eye Center — Louisville, Kentucky, United States
• Eastern Maine Medical Center — Bangor, Maine, United States
• Ophthalmology Associates — St Louis, Missouri, United States
• Comprehensive Eye Care Ltd — Washington, Missouri, United States
• David M. Ringel, DO, PA — Sewell, New Jersey, United States
• Brar-Parekh Eye Associates — Woodland Park, New Jersey, United States
• Ophthalmic Consultants of Long Island — Lynbrook, New York, United States
• Park Ophthalmology — Durham, North Carolina, United States
• Ohio State University - College of Optometry — Columbus, Ohio, United States
• Columbus Ophthalmology Associates — Columbus, Ohio, United States
• Philadelphia Eye Associates — Philadelphia, Pennsylvania, United States
• Total Eye Care, PA — Memphis, Tennessee, United States

Full record on ClinicalTrials.gov

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