Multimodal Neuroimaging of Treatment Effects in Adolescent Mania

Completed · Not applicable · Has a placebo group

Conditions studied: Mania, Bipolar Disorder

In brief

Specific Aim 1: To determine the effects of treatment with quetiapine or lithium on brain activation in adolescents. The investigators will use functional magnetic resonance imaging (fMRI) to examine brain activation during an attentional task. Specific Aim 2: To determine the effects of treatment with quetiapine or lithium on neurometabolite measures, early in their illness course. The investigators will use 1H-MRS to identify myo-inositol (mI), N-acetyl aspartate (NAA), and glutamate (Glu) levels in prefrontal ALN regions. Specific Aim 3: To determine the relationships among the changes in brain activation and neurometabolite measures, as well as symptomatic improvement in manic adolescents.

Key facts

Study ID
NCT00893581
Run by
University of Cincinnati
People needed
169
Starts
2009-03-01
Expected to finish
2016-03-01
Last updated by the study team
2016-05-19

Who can join

Age: 12 and older, up to 17. Sex: any. Healthy volunteers: accepted.

Where it is running

Full record on ClinicalTrials.gov

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