The Effects of Azithromycin Ophthalmic Solution, 1% Versus Placebo in Subjects With Blepharitis During a Two-Week Treatment Period

Completed · Phase 2 · Has a placebo group

Conditions studied: Blepharitis

In brief

The objective of this study is to compare the safety and efficacy of azithromycin ophthalmic solution, 1% versus placebo over a two-week treatment period.

Key facts

Study ID

NCT00892970

Run by

Merck Sharp & Dohme LLC

People needed

313

Starts

2009-04-01

Expected to finish

2010-01-01

Last updated by the study team

2011-09-26

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Have best corrected visual acuity in both eyes of at least +0.7 or better
• If female, are non-pregnant or non-lactating
• Have a current diagnosis of blepharitis in one or both eyes

You may not qualify if…

• Have lid structural abnormalities
• Have suspected ocular fungal or viral infection
• Have practiced warm compress therapy within 14 days prior to Visit 2
• Unable to withhold the use of contact lenses during the treatment or follow-up periods
• Unable to withhold the use of ocular cosmetic products within 24 hours prior to study visits
• Have had penetrating intraocular surgery within 90 days prior to Visit 2
• Have had ocular surface surgery within the past year prior to Visit 2
• Have a serious medical condition which could confound study assessments

Where it is running

• Jones Eye Institute — Little Rock, Arkansas, United States
• Sall Medical Research Center — Artesia, California, United States
• Milton Hom, OD — Azusa, California, United States
• The Jules Stein Eye Institute UCLA Laser Refractive Center — Los Angeles, California, United States
• North Valley Eye Medical Group — Mission Hills, California, United States
• David Wirta, MD, Inc. — Newport Beach, California, United States
• North Bay Eye Associates — Petaluma, California, United States
• West Coast Eye Care — San Diego, California, United States
• Wolstan Eye Associates — Torrence, California, United States
• Eye Center - A Medical and Surgical Group — Hamden, Connecticut, United States
• Florida Eye Microsurgical Institute — Boynton Beach, Florida, United States
• Eye Centers of Florida — Fort Myers, Florida, United States
• NorthShore University HealthSystems — Glenview, Illinois, United States
• Chicago Cornea Consultants — Hoffman Estates, Illinois, United States
• Indiana University School of Medicine, Ophthalmology Dept. — Indianapolis, Indiana, United States
• Eye Physicians and Surgeons, LLP — Iowa City, Iowa, United States
• Koffler Vision Group — Lexington, Kentucky, United States
• Wilmer Eye Institute, Johns Hopkins Hospital — Baltimore, Maryland, United States
• Ophthalmic Consultants of Boston — Boston, Massachusetts, United States
• Minnesota Eye Consultants — Minneapolis, Minnesota, United States
• Ophthalmology Associates — St Louis, Missouri, United States
• Ophthalmology Consultants — St Louis, Missouri, United States
• Brar-Parekh Eye Associates — Woodland Park, New Jersey, United States
• South Shore Eye Care — Wantagh, New York, United States
• Mundorf Eye Center — Charlotte, North Carolina, United States

Full record on ClinicalTrials.gov

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