Stress Resilience Study

Completed

Conditions studied: Oxidative Stress, Aging

In brief

The purpose of this study is to test the hypothesis that physiological adaptations to regular exercise training (i.e. physical fitness) attenuates age-related decline in stress resilience to both oxidative stress and the neuroendocrine responses to psychosocial stress.

Key facts

Study ID

NCT00891488

Run by

Kronos Longevity Research Institute

People needed

80

Starts

2008-07-01

Expected to finish

2010-05-01

Last updated by the study team

2010-08-03

Who can join

Age: 60 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Men and post-menopausal women, ages 60-80 years
• Generally good health by self-report

You may not qualify if…

• Estrogen or testosterone supplementation within the previous 6 months
• Current smoker
• Body Mass Index (BMI) > 32 kg/m2
• Any chronic illness that could affect cortisol levels, including diabetes mellitus, liver or renal disease
• Evidence of a previous myocardial infarction within the last 6 months by EKG or history of angina or shortness of breath
• Clinically significant arrhythmia on a resting EKG or significant EKG changes during the baseline VO2max test
• Any other condition that would contraindicate maximal exercise testing, including elevated blood pressure at rest (systolic BP >140 or diastolic BP >90 mm Hg on at least 2 measurements, at least 10 minutes apart) or musculoskeletal problems
• Depression as measured by the Beck Depression Inventory (BDI score >17)
• Use of anti-oxidant supplements, in excess of standard multi-vitamins (1 tablet/day)

Where it is running

• Kronos Longevity Research Institute — Phoenix, Arizona, United States

Full record on ClinicalTrials.gov

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