Satiety Response After Mixed Fiber Doses

Completed · Not applicable

Conditions studied: Satiety

In brief

People who eat more dietary fiber have a lower body weight than people who eat less fiber. Potential mechanisms include greater feelings of satiety, reductions in food intake, changes in blood glucose, insulin, or gut hormones. The investigators hypothesize that increasing doses of mixed fiber will influence satiety response, food intake, glucose, insulin, ghrelin, GLP-1, and PYY 3-36, in a dose-dependent manner, when given to subjects in muffins for breakfast.

Key facts

Study ID

NCT00889993

Run by

University of Minnesota

People needed

20

Starts

2007-11-01

Expected to finish

2008-10-01

Last updated by the study team

2012-03-29

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• English speaking
• healthy men and women
• 18 and 65 years of age
• non-smoking
• not taking medications
• non-dieting (weight stable over last 3 months)
• BMI between 18 and 27
• able to give blood through an IV

You may not qualify if…

• irregular or erratic breakfast eating patterns
• food allergies to ingredients commonly found in muffins or pizza
• distaste for muffins or pizza
• BMI less than 18 or greater than 27
• weight change > 5 kg in last 3 months (intentional or unintentional)
• cardiovascular disease
• diabetes mellitus (fasting blood sugar > 126 mg/dl)
• cancer in prior 5 years (except basal cell carcinoma of skin)
• renal or hepatic disease
• Crohns disease
• ulcerative colitis
• any other gastrointestinal conditions that may affect digestion or absorption
• recent bacterial infection (< 3 months)
• chronic medication use
• history of drug or alcohol abuse in prior 6 months
• concurrent or recent intervention study participation
• vegetarians
• people who ate more than approximately 15 g of fiber per day
• pregnant or lactating women
• women with irregular menstrual cycles

Where it is running

• University of Minnesota: General Clinical Research Center — Minneapolis, Minnesota, United States

Full record on ClinicalTrials.gov

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