Radiation Therapy With Concomitant and Adjuvant Temozolomide Versus Radiation Therapy With Adjuvant PCV Chemotherapy in Patients With Anaplastic Glioma or Low Grade Glioma
Running, not enrolling · Phase 3
Conditions studied: Brain and Central Nervous System Tumors
In brief
Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether giving radiation with concomitant and adjuvant temozolomide versus radiation with adjuvant PCV is more effective in treating anaplastic glioma or low grade glioma.
Key facts
- Study ID
- NCT00887146
- Run by
- Alliance for Clinical Trials in Oncology
- People needed
- 305
- Starts
- 2009-09-01
- Expected to finish
- 2029-10-31
- Last updated by the study team
- 2026-01-22
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Providence Hospital — Mobile, Alabama, United States
- Anchorage Associates in Radiation Medicine — Anchorage, Alaska, United States
- Alaska Oncology and Hematology LLC — Anchorage, Alaska, United States
- Alaska Women's Cancer Care — Anchorage, Alaska, United States
- Anchorage Oncology Centre — Anchorage, Alaska, United States
- Katmai Oncology Group — Anchorage, Alaska, United States
- Providence Alaska Medical Center — Anchorage, Alaska, United States
- Saint Joseph's Hospital and Medical Center — Phoenix, Arizona, United States
- Arizona Oncology-Deer Valley Center — Phoenix, Arizona, United States
- Arizona Oncology Services Foundation — Scottsdale, Arizona, United States
- Kaiser Permanente-Anaheim — Anaheim, California, United States
- Sutter Cancer Centers Radiation Oncology Services-Auburn — Auburn, California, United States
- Mills-Peninsula Medical Center — Burlingame, California, United States
- Sutter Cancer Centers Radiation Oncology Services-Cameron Park — Cameron Park, California, United States
- Community Cancer Institute — Clovis, California, United States
- University Oncology Associates — Clovis, California, United States
- UC San Diego Moores Cancer Center — La Jolla, California, United States
- Kaiser Permanente Los Angeles Medical Center — Los Angeles, California, United States
- Cedars Sinai Medical Center — Los Angeles, California, United States
- Memorial Medical Center — Modesto, California, United States
- Kaiser Permanente Oakland-Broadway — Oakland, California, United States
- Kaiser Permanente-Ontario — Ontario, California, United States
- UC Irvine Health/Chao Family Comprehensive Cancer Center — Orange, California, United States
- Sutter Cancer Centers Radiation Oncology Services-Roseville — Roseville, California, United States
- University of Alabama at Birmingham Cancer Center — Birmingham, Alabama, United States
Full record on ClinicalTrials.gov
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