Ghrelin and Insulin Resistance

Completed · Phase 1

Conditions studied: Obesity, Insulin Resistance, Normal Weight,Healthy Controls

In brief

Ghrelin, a hormone produced in the stomach that stimulates hunger and food intake, declines immediately after weight loss surgery. Some studies suggest that ghrelin may worsen an individual's ability to respond to insulin. The purpose of this study is to determine if the decline in ghrelin levels after weight loss surgery contributes to the improvement of insulin sensitivity.

Key facts

Study ID

NCT00884494

Run by

Vanderbilt University Medical Center

People needed

20

Starts

2011-08-01

Expected to finish

2014-05-01

Last updated by the study team

2017-01-20

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may not qualify if…

• Prior bariatric surgery
• Serum creatinine > 1.5 mg/dl
• Hepatic enzyme elevations > 2x upper limits of normal
• Current use of warfarin or clopidogrel
• Intercurrent infections
• Females with positive pregnancy test
• Abnormal ECG

Where it is running

• Vanderbilt University Medical Center — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

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