Anecortave Acetate Injection to Treat Steroid-responsive Intraocular Pressure Increase in Cornea Transplant Patients

Stopped early · Not applicable

Conditions studied: Transplant, Intraocular Pressure

In brief

This study will investigate the use of anecortave acetate injection to reduce intraocular pressure (IOP) in corneal transplant recipients who are experiencing steroid-associated pressure control problems. Alternative methods of IOP control have been shown to entail serious risks. For example, reduction of topical steroids increases the risk of graft rejection, and use of glaucoma medications or glaucoma surgery increases the risk of graft failure. This study is designed to have sufficient power to detect whether a single injection can induce a clinically significant IOP reduction.

Key facts

Study ID

NCT00884039

Run by

Cornea Research Foundation of America

People needed

7

Starts

2009-05-01

Expected to finish

2010-09-01

Last updated by the study team

2018-08-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• at least 18 years of age
• corneal transplant recipient with intraocular pressure (IOP) greater than 24 mmHg and with relative increase in IOP of at least 10 mmHg over the pre-graft baseline

You may not qualify if…

• not pregnant or lactating
• intraocular surgery in the study eye within 30 days before enrolling in the study
• use of any investigational drug or treatment within 30 days before receipt of study medication
• clinical evidence of scleral thinning

Where it is running

• Price Vision Group — Indianapolis, Indiana, United States

Full record on ClinicalTrials.gov

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