Race, Menopause and Metabolism After Exercise and Diet

Completed · Not applicable

Conditions studied: Obesity, Insulin Resistance, Sedentary Lifestyle

In brief

The purpose of this study is to test the hypotheses that there are ethnic and genetic differences in the mechanisms and magnitude by which hypocaloric weight loss and aerobic exercise affect body composition, glucose, lipid, muscle and adipose tissue metabolism in overweight, insulin resistant postmenopausal women. This will be tested in a trial comparing the effects of weight loss vs. aerobic exercise plus weight loss on glucose, lipid, fat and muscle metabolism in overweight African American and Caucasian postmenopausal women.

Key facts

Study ID

NCT00882141

Run by

National Institute on Aging (NIA)

People needed

103

Starts

2002-03-01

Expected to finish

2008-12-01

Last updated by the study team

2010-01-13

Who can join

Age: 45 and older, up to 80. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Female
• 45-80 yrs of age
• Non-smoking for one year
• BMI greater than 25 kg/m2 and less than 50 kg/m2
• Menopause over 1 year
• Caucasian or African American ethnicity

You may not qualify if…

• Both groups
• Currently being treated for active cancer
• Type 1 diabetes; insulin treatment; poorly controlled (fasting blood sugar over 160 mg/dl)
• Allergic to lidocaine or heparin
• Untreated dyslipidemia, receiving triglyceride-lowering meds
• Other systemic disorders that are not medically treated and stable
• Taking beta-blockers, oral steroids, warfarin or any other medications interfering with fat/muscle metabolism that may not be safely discontinued temporarily for specific procedures (i.e. for 72 hours prior)
• Abnormal liver or renal function; chronic pulmonary disease (on supplemental oxygen); anemia
• MMSE (Mini-Mental State Examination) below 24, dementia or unstable clinical depression by exam
• Women of ethnicity other than Caucasian or African American
• Symptomatic heart disease, coronary artery disease, congestive heart failure, or uncontrolled hypertension unless medically stabilized
• Abnormal response to exercise test (chest pain, significant arrhythmias, extreme shortness of breath, cyanosis, exercising blood pressure above 240/120mm Hg, or other contraindications to exercise)
• Exercise plus weight loss group only
• Medical history of CVD (cardiovascular disease) with symptoms limiting ability to exercise
• Physical impairment limiting normal activity
• Aerobically trained with VO2max greater than 2 SD (standard deviation) above age-adjusted mean

Where it is running

• University of Maryland, VAMC — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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