Treatment Outcome With a Revascularization Protocol Using the Triple Versus Double Antibiotic Paste

Completed · Early Phase 1

Conditions studied: Pulp Necrosis

In brief

The purpose of this study is to determine the treatment outcomes in permanent teeth with necrotic pulp and immature root development that undergo a regenerative procedure using a triple antibiotic paste (ciprofloxacin, metronidazole, minocycline) versus a double antibiotic paste (ciprofloxacin, metronidazole)compared to the commonly used mineral trioxide aggregate (MTA) apexification treatment.

Key facts

Study ID

NCT00881491

Run by

The University of Texas Health Science Center at San Antonio

People needed

10

Starts

2009-04-01

Expected to finish

2015-01-01

Last updated by the study team

2016-02-05

Who can join

Age: 7 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• diagnosis of pulpal necrosis with apical periodontitis
• patients 7-60 years of age
• maxillary or mandibular restorable single rooted immature permanent tooth with open apices
• acceptance of treatment plan with revascularization procedure
• healthy patient (ASA Class I or II physical status) with no systemic health problems

You may not qualify if…

• non-restorable teeth
• patients with ASA Class III or IV physical status (Immuno-compromised patients including patients who self-report to be a carrier of HIV, undergoing steroid therapy, or those who self-report with genetic or systemic diseases that could result in reduced immune response.
• child subjects unable to give assent

Where it is running

• University of Texas Health Science Center at San Antonio — San Antonio, Texas, United States

Full record on ClinicalTrials.gov

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