Study of the Efficiency of Esophageal Dilation on Patient With Eosinophilic Esophagitis

Completed · Not applicable

Conditions studied: Suspected Eosinophilic Esophagitis

In brief

This study is for patients who have had a food impaction and/or difficulty swallowing, who are scheduled to have endoscopy, biopsy and possibly dilatation (stretching) of the esophagus. Standard treatment for people who have food impaction and difficulty swallowing is endoscopy to view the esophagus, tissue biopsies of the lining of the esophagus for diagnosis, and drug therapy including steroids and drugs used to treat reflux disease. Early dilatation or stretching of the esophagus may be done at this time but not always. Some doctors prefer to wait and see if the drugs are affective. It is not known if dilating the esophagus early in treatment adds benefit. Therefore, we are doing this study to compare the two methods of treatment. We will compare two groups: one group will have dilatation performed during the first endoscopy and one group will not have dilatation performed during endoscopy. We will see if dilatation helps prevent food impaction and improves swallowing. Another purpose of this study is to learn more about the causes of swallowing problems, thus extra biopsies will be taken of the esophagus and store them for future research.

Key facts

Study ID

NCT00880906

Run by

Vanderbilt University

People needed

50

Starts

2008-08-01

Expected to finish

2013-12-01

Last updated by the study team

2017-11-06

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male and female volunteers ≥18 years old.
• Patients with known or suspected Eosinophilic Esophagitis.
• Patients undergoing upper endoscopy for recent food impaction or complaint of dysphagia.

You may not qualify if…

• Use of oral corticosteroids.
• Significant medical conditions that in the investigator's judgment would compromise the subject's health and safety.
• Contraindication to esophageal dilation based on investigator's judgment.
• Esophageal motility abnormalities not thought to be related to Eosinophilic Esophagitis.

Where it is running

• Vanderbilt Unversity Medical Center Department of Gastroenterology — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

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