Semantic Memory, Financial Capacity, and Brain Perfusion in Mild Cognitive Impairment (MCI) (CASL)

Completed

Conditions studied: Alzheimer Disease, Dementia

In brief

Alzheimer's disease (AD) often manifests as a memory disorder before dementia develops. Dementia is considered to be present when a person can no longer handle complex activities of daily living, such as managing finances. This study will investigate the relationship between changes in the ability to manage finances and brain perfusion, which will be measured using continuous arterial spin-labeling (an experimental MRI). Subjects will also undergo neuropsychological tests focusing on several types of memory and thought process, with special emphasis on semantic memory. An important question to be addressed is whether changes in function are better predicted by the neuropsychological tests or by the brain scan.

Key facts

Study ID

NCT00880555

Run by

VA Office of Research and Development

People needed

78

Starts

2009-04-01

Expected to finish

2014-05-01

Last updated by the study team

2016-03-24

Who can join

Age: 50 and older, up to 89. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Veteran or non-veteran
• Age 50-89
• With normal cognition or memory impairment (MCI or mild AD)
• English speaking
• Right handed
• Adequate vision and hearing to take part in tests
• Able and willing to undergo MRI scan
• Medically and psychiatrically stable
• No other brain disease (such as tumor, Parkinson's disease, major stroke)

You may not qualify if…

• Pregnancy
• Inability to tolerate MRI (due to metal in body or claustrophobia)

Where it is running

• Birmingham VA Medical Center, Birmingham, AL — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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