Plaque Inflammation and Dysfunctional HDL in AIM-HIGH

Completed

Conditions studied: Cardiovascular Diseases, Heart Diseases, Coronary Disease, Atherosclerosis, Myocardial Infarction

In brief

Coronary heart disease (CHD) is a serious health concern that affects millions of people in the United States. It is usually caused by atherosclerosis-a condition that occurs when fatty material and plaque build up on the walls of the arteries that supply blood and oxygen to the heart, causing the arteries to narrow. As the arteries narrow, blood flow to the heart can slow down or stop, which can cause chest pain, shortness of breath, heart attack, or heart failure. Another component of CHD events involves inflammatory changes that result in structural breakdown of atherosclerotic plaques. Adding niacin to statin medications may be an effective way to block inflammation in the atherosclerotic plaques. This study will examine magnetic resonance imaging (MRI) images and blood samples of participants in the AIM-HIGH study who are taking niacin plus statins or statins alone to determine the effect of these medications on inflammation in atherosclerotic plaques.

Key facts

Study ID

NCT00880178

Run by

University of Washington

People needed

324

Starts

2008-05-01

Expected to finish

2011-09-01

Last updated by the study team

2018-05-14

Who can join

Age: 45 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Eligible for main AIM-HIGH study (NCT00120289)
• Willing to provide informed consent for participation in this substudy

Where it is running

• Cardiovascular Associates — Birmingham, Alabama, United States
• Cardiovascular Consultants — Phoenix, Arizona, United States
• Long Beach VA Medical Center — Long Beach, California, United States
• Christiana Care Health Services — Newark, Delaware, United States
• University of Maryland — Baltimore, Maryland, United States
• University of Minnesota — Minneapolis, Minnesota, United States
• HealthPartners Riverside Clinic — Minneapolis, Minnesota, United States
• Mayo Clinic — Rochester, Minnesota, United States
• Duke University — Durham, North Carolina, United States
• Wake Forest University, Geriatrics — Greensboro, North Carolina, United States
• Wake Forest University, Cardiology — Winston-Salem, North Carolina, United States
• Wake Forest University, Endocrinology — Winston-Salem, North Carolina, United States
• St. Vincent Charity Hospital — Cleveland, Ohio, United States
• Portland VA Medical Center — Portland, Oregon, United States
• Philadelphia VA Medical Center — Philadelphia, Pennsylvania, United States
• Pennsylvania Cardiology Associates — Philadelphia, Pennsylvania, United States
• Cardiology Consultants of Philadelphia — Philadelphia, Pennsylvania, United States
• Baylor College of Medicine — Houston, Texas, United States
• Kelsey Research Foundation — Houston, Texas, United States
• Methodist Hospital — Houston, Texas, United States
• McGuire VA Medical Center — Richmond, Virginia, United States
• Harborview Medical Center — Seattle, Washington, United States
• University of Washington — Seattle, Washington, United States
• Puget Sound VA Medical Center, Seattle Campus — Seattle, Washington, United States
• Heart Health Institute — Calgary, Alberta, Canada

Full record on ClinicalTrials.gov

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