Pharmacogenetics of Nicotine Metabolism in African-Americans

Completed · Phase 1

Conditions studied: Cigarette Smoking

In brief

The investigators hypothesize that African Americans (AAs) smoke more for positive reinforcement from nicotine with a "peak-seeking" pattern of smoking (smoking individual cigarettes more intensively with greater intake of nicotine and tobacco smoke toxins), while whites smoke more for negative reinforcement with a "trough-maintaining" pattern (avoiding withdrawal by maintaining more consistent nicotine levels throughout the day by means of a more regular smoking pattern). The investigators believe that these patterns are linked to identifiable racial differences in nicotine pharmacology and that there will be associated racial differences in responses to pharmacologic interventions.

Key facts

Study ID

NCT00879918

Run by

University of California, San Francisco

People needed

70

Starts

2008-12-01

Expected to finish

2012-03-01

Last updated by the study team

2013-05-24

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• African-American
• Age 18-65
• Smoke at least 5 cigarettes per day

You may not qualify if…

• Significant health conditions
• Drug use
• Pregnancy or breastfeeding
• Inability to read English

Where it is running

• University of California San Francisco/SFGH — San Francisco, California, United States

Full record on ClinicalTrials.gov

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