Disulfiram Interactions With HIV Medications: Clinical Implications

Completed · Phase 1

Conditions studied: HIV Infections, Drug Abuse

In brief

The purpose of this study is to determine whether disulfiram might be a safe and effective treatment for cocaine and/or alcohol dependence in patients with HIV disease. This research is designed to characterize the presence or absence of significant drug interactions between disulfiram and HIV medications using standard clinical pharmacology techniques as well as monitor any side effects that might occur when these medications are administered together.

Key facts

Study ID

NCT00878306

Run by

University of California, San Francisco

People needed

40

Starts

2008-11-01

Expected to finish

2013-04-01

Last updated by the study team

2014-05-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Good health and without clinical findings that require medical or psychiatric intervention as determined by a physical and mental status examination and screening laboratory tests, urinalysis, and ECG
• 18 years of age or older
• Willing to abstain from alcohol during the study and for two weeks afterward

You may not qualify if…

• Patients who are receiving concurrently other drugs that are inducers or inhibitors of hepatic microsomal enzymes
• Patients with a known sensitivity to the HIV therapeutics to be studied
• Pregnant or nursing mothers
• Current major affective or psychotic illnesses or suicidality
• Clinically active hepatitis
• Diabetes, hyperlipidemia, coagulation disorders, or renal disease will be excluded
• Those meeting criteria for current alcohol or drug dependence (other than nicotine)
• HIV infection

Where it is running

• San Francisco General Hospital — San Francisco, California, United States

Full record on ClinicalTrials.gov

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