A Trial In Patients With Advanced Cancer And Leukemia

Completed · Phase 1

Conditions studied: Neoplasms by Histologic Type

In brief

This is a phase 1, dose escalating study to determine the safety of PF-03084014 in patients with advanced cancer and leukemia

Key facts

Study ID

NCT00878189

Run by

Pfizer

People needed

72

Starts

2009-06-25

Expected to finish

2016-11-22

Last updated by the study team

2019-11-12

Who can join

Age: 16 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with advanced cancer that is resistant to standard therapy or for which no standard therapy is available
• Patients with acute T cell leukemia/lymphoblastic lymphoma that is resistant to standard therapy or for which no standard therapy is available
• Men and women >16 years old

You may not qualify if…

• Prior treatment with a gamma secretase inhibitor for treatment of cancer
• Patients taking Tamoxifen
• Patients with active graft versus host disease
• Known human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) related illness
• Patients who are pregnant or breast feeding
• Patients with clinical evidence of central nervous system disease

Where it is running

• Anschutz Cancer Pavilion — Aurora, Colorado, United States
• University of Colorado Denver CTRC — Aurora, Colorado, United States
• University of Colorado Hospital — Aurora, Colorado, United States
• Massachusetts General Hospital Clinical Laboratory — Boston, Massachusetts, United States
• Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States
• Dana Ferber Cancer institute — Boston, Massachusetts, United States
• Karmanos Cancer Center / Wayne State University — Detroit, Michigan, United States
• The University of Texas MD Anderson Cancer Center — Houston, Texas, United States
• DIPRTMNT CLIN Scienze RADIOL e Istocitopatologiche — Bologna, Italy
• Istituto di Ematologia Seragnoli — Bologna, Italy

Full record on ClinicalTrials.gov

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