GDC-0449 and Erlotinib Hydrochloride With or Without Gemcitabine Hydrochloride in Treating Patients With Metastatic Pancreatic Cancer or Solid Tumors That Cannot Be Removed by Surgery

Running, not enrolling · Phase 1

Conditions studied: Adult Solid Neoplasm, Pancreatic Acinar Cell Carcinoma, Pancreatic Ductal Adenocarcinoma, Recurrent Pancreatic Carcinoma, Stage IV Pancreatic Cancer AJCC v6 and v7

In brief

This phase I trial is studying the side effects and best dose of erlotinib hydrochloride when given together with GDC-0449 with or without gemcitabine hydrochloride in treating patients with metastatic pancreatic cancer or solid tumors that cannot be removed by surgery. Drugs used in chemotherapy, such as GDC-0449 and gemcitabine hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Erlotinib hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving GDC-0449 together with erlotinib hydrochloride with or without gemcitabine hydrochloride may kill more tumor cells.

Key facts

Study ID

NCT00878163

Run by

National Cancer Institute (NCI)

People needed

55

Starts

2009-03-31

Expected to finish

2027-03-06

Last updated by the study team

2026-04-13

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Histologic proof of a solid tumor that is now unresectable, not amenable to any other standard therapies, or patient refuses standard therapy
• Metastatic adenocarcinoma of the pancreas amenable to biopsies (cohort II MTD only)
• Absolute neutrophil count (ANC) >= 1,500/μL
• Platelets >= 100,000/μL
• Total bilirubin =< upper limit of normal (ULN)
• Aspartate aminotransferase (AST) =< 3 times upper limit of normal (ULN)
• Creatinine =< 1.5 times ULN
• Hemoglobin >= 9.0 g/dL
• International Normalized Ratio (INR) within normal limits (for patients treated at the MTD)
• Ability to provide informed consent
• Willingness to return to Mayo Clinic for follow up
• Life expectancy >= 12 weeks
• Willingness to provide the biologic specimens as required by the protocol
• Negative serum pregnancy test done =< 7 days prior to registration
• Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0-2
• Able to swallow or have medication administered through a G-tube and absorb the medication
• Participant agrees to use an acceptable form of contraception; acceptable forms of contraception:
• Latex condom (always used with spermicide)
• Diaphragm (always used with spermicide)
• Cervical cap (always used with spermicide)
• Acceptable forms of secondary contraceptions, when used along with a barrier method:
• Hormonal contraception methods, including pills, patches, rings, or injections except progestin-only containing pills (i.e. "Mini-pill")
• Tubal ligation
• Partner's vasectomy
• Intrauterine device (IUD) (non-progesterone T)

You may not qualify if…

• Known standard therapy for the patient's disease that is potentially curative or definitely capable of extending life expectancy
• Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
• Any of the following prior therapies:
• Chemotherapy =< 4 weeks prior to registration
• Mitomycin C/nitrosoureas =< 6 weeks prior to registration
• Immunotherapy =< 4 weeks prior to registration
• Biologic therapy =< 4 weeks prior to registration
• Radiation therapy =< 4 weeks prior to registration
• Radiation to > 25% of bone marrow
• Failure to fully recover from acute, reversible effects of prior therapy regardless of interval since last treatment
• New York Heart Association classification III or IV
• Seizure disorder
• Central nervous system (CNS) metastases if not stable for at least 2-3 months based on imaging, clinical assessment, and use of steroids, or seizure disorder
• Pregnant women
• Nursing women
• Men or women of childbearing potential who are unwilling to employ adequate contraception until 12 months after last study drug dose
• Other concurrent chemotherapy, immunotherapy, radiotherapy, or any ancillary therapy considered investigational (utilized for a non-Food and Drug Administration [FDA]-approved indication and in the context of a research investigation)
• Current therapy with a CYP3A4 inhibitor or inducer
• Immunocompromised patients (other than that related to the use of corticosteroids) including patients receiving highly active antiretroviral therapy (HAART) treatment
• Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm
• Active other malignancy, excepting non-melanotic skin cancer or carcinoma-in-situ of the cervix; if there is a history of prior malignancy, they must not be receiving other specific treatment (other than hormonal therapy) for their cancer
• History of myocardial infarction =< 6 months, or congestive heart failure requiring use of ongoing maintenance therapy for life-threatening ventricular arrhythmias
• Abnormalities of the cornea based on history (e.g., dry eye syndrome, Sjogren's syndrome), congenital abnormality (e.g., Fuch's dystrophy), abnormal slit-lamp examination using a vital dye (e.g., fluorescein, Bengal Rose), and/or an abnormal corneal sensitivity test (Schirmer test or similar tear production test)
• More than 2 prior chemotherapy regimens for the current metastatic malignancy; full dose chemotherapy used in conjunction with concurrent radiation therapy will be included as prior therapy; Note: prior hormonal therapy (e.g. leuprolide, aromatase inhibitors, tamoxifen) will be allowed and not included as a prior chemotherapy
• Previous therapy with a hedgehog inhibitor

Where it is running

• Mayo Clinic in Arizona — Scottsdale, Arizona, United States
• Mayo Clinic in Florida — Jacksonville, Florida, United States
• Orlando Health Cancer Institute — Orlando, Florida, United States
• Mayo Clinic in Rochester — Rochester, Minnesota, United States

Full record on ClinicalTrials.gov

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