Life Improvement Following Traumatic Brain Injury

Completed · Not applicable

Conditions studied: Traumatic Brain Injury, Depression

In brief

The purpose of this study is to test the effectiveness of a telephone-based and in-person Cognitive Behavioral Therapy (CBT) intervention for treating Major Depressive Disorder (MDD) following Traumatic Brain Injury. Participants are randomly assigned to receive one of the following: 1) Telephone-based CBT, 2) In-person CBT, or 3) Usual care (control).

Key facts

Study ID: NCT00878150
Run by: University of Washington
People needed: 100
Starts: 2007-09-01
Expected to finish: 2013-09-01
Last updated by the study team: 2013-10-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

hospitalized for TBI within the last 10 years, and at least one month post-injury
sustained a complicated mild to severe TBI as indicated by Glasgow Coma Scale score of 3-12 or had documented intracranial abnormalities on CT scan or had post-traumatic amnesia (PTA) of at least 7 days
meet screening criteria for major depression
speak English fluently
resides in any of the the 50 United States

You may not qualify if…

does not have a telephone
does not have a stable address
history of bipolar disorder or schizophrenia, or current psychosis or suicidal intent
current alcohol or substance dependence (within last month)
evidence of significant cognitive impairment on neuropsychological testing
started on an antidepressant medication within 6 weeks or planning to start on an antidepressant within the 16-week study
currently in psychotherapy for depression or plan to start psychotherapy for depression within the 16-week study period
refusal to participate

Where it is running

University of Washington School of Medicine — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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