Functional Magnetic Resonance Imaging (fMRI) and Robot-Assisted Practice of Activities of Daily Living
Completed · Phase 1
Conditions studied: Hemiparesis, Ischemic Stroke, Chronic
In brief
The investigators will study motor recovery after robot-assisted therapy after stroke. A small clinical trial will be conducted to quantify the central nervous system changes associated with robotic or standard training, and identify trends across high and low responders in terms of patterns of change in cortical activity and type of white matter connectivity.The investigators hypothesize that robot training will lead to larger improvements as compared to standard occupational therapy. The investigators hypothesize that high responders to the robot training will have reduced compensatory activation in the bilateral area and will connectivity in the motor tracts.
Key facts
- Study ID
- NCT00878085
- Run by
- Medical College of Wisconsin
- People needed
- 61
- Starts
- 2008-11-01
- Expected to finish
- 2013-06-01
- Last updated by the study team
- 2014-02-04
Who can join
Age: 30 and older, up to 85. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Stroke:
- 30 to 85 years
- Right-handed (evaluated with handedness survey)
- suffered a unilateral ischemic stroke in the motor control area, which resulted in hemiparesis of the arm (confirmed by medical data),
- at least 6-months post-stroke
- residual movement at least (a) 15 degree shoulder flexion or adduction, (b) 15 degree active elbow flexion and extension
- not claustrophobic
- not depressed (as measured depression survey)
- able to use the scanner, i.e., passes the fMRI screening survey
- able to understand the instructions and complete the tracking tasks Control
- older than 20 years
- Right-handed (evaluated with survey)
- not claustrophobic
- able to use the scanner, i.e., passes the fMRI screening survey
- able to understand the instructions and complete the tracking tasks
- no history of neurological disorders --not depressed (as measured depression survey)
You may not qualify if…
- Stroke:
- brain stem, stroke
- pre-existing neurological or psychiatric disorders
- Spasticity >3 at elbow or fingers on Ashworth
- demonstrated visuospatial, language or attention deficits of a severity that prevents understanding the task
- shoulder pain or joint pain during movements
- synkinetic movements or mirror movements
- decline to participate
- will not comply with full protocol
- pregnant
- allergic to goretex and conductivity gel
- Control
- decline to participate
- will not comply with full protocol
- pregnant
- allergic to goretex and conductivity gel
Where it is running
- Medical College of Wisconsin — Milwaukee, Wisconsin, United States
- Clement J Zablocki VA — Milwaukee, Wisconsin, United States
Full record on ClinicalTrials.gov
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