Study of Bendamustine Hydrochloride and Rituximab (BR) Compared With R-CVP or R-CHOP in the First-Line Treatment of Patients With Advanced Indolent Non-Hodgkin's Lymphoma (NHL) or Mantle Cell Lymphoma (MCL) - Referred to as the BRIGHT Study

Completed · Phase 3

Conditions studied: Non-Hodgkin's Lymphoma, Mantle Cell Lymphoma

In brief

The primary objective of the study is to compare the complete response (CR) rate of bendamustine and rituximab (BR) with that of standard treatment regimens of either rituximab, cyclophosphamide, vincristine, and prednisone (R-CVP) or rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) in patients with advanced, indolent non-Hodgkin's lymphoma (NHL) or mantle cell lymphoma (MCL).

Key facts

Study ID

NCT00877006

Run by

Teva Branded Pharmaceutical Products R&D, Inc.

People needed

447

Starts

2009-04-30

Expected to finish

2012-03-31

Last updated by the study team

2018-02-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Teva Investigational Site 167 — Little Rock, Arkansas, United States
• Teva Investigational Site 11 — Corona, California, United States
• Teva Investigational Site 21 — Fountain Valley, California, United States
• Teva Investigational Site 52 — Fountain Valley, California, United States
• Teva Investigational Site 64 — Fullerton, California, United States
• Teva Investigational Site 40 — Los Angeles, California, United States
• Teva Investigational Site 53 — Los Angeles, California, United States
• Teva Investigational Site 57 — San Diego, California, United States
• Teva Investigational Site 15 — Aurora, Colorado, United States
• Teva Investigational Site 155 — Denver, Colorado, United States
• Teva Investigational Site 5 — Fort Collins, Colorado, United States
• Teva Investigational Site 70 — New Britain, Connecticut, United States
• Teva Investigational Site 37 — Norwalk, Connecticut, United States
• Teva Investigational Site 67 — Southington, Connecticut, United States
• Teva Investigational Site 58 — Fort Myers, Florida, United States
• Teva Investigational Site 38 — Hollywood, Florida, United States
• Teva Investigational Site 23 — Jacksonville, Florida, United States
• Teva Investigational Site 65 — Lake Worth, Florida, United States
• Teva Investigational Site 156 — Miami, Florida, United States
• Teva Investigational Site 160 — Orlando, Florida, United States
• Teva Investigational Site 68 — Orlando, Florida, United States
• Teva Investigational Site 72 — Augusta, Georgia, United States
• Teva Investigational Site 50 — Columbus, Georgia, United States
• Teva Investigational Site 73 — Macon, Georgia, United States
• Teva Investigational Site 165 — Tucson, Arizona, United States

Full record on ClinicalTrials.gov

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