Effect of ACE-inhibitors on Aortic Stiffness in Elderly Patients With Chronic Kidney Disease

Completed · Phase 2 · Has a placebo group

Conditions studied: Cardiovascular Disease, Chronic Kidney Disease

In brief

The goal of this proposal is to investigate the potential for ACE-inhibitors (ACE-I)(drugs primarily used to treat hypertension or congestive heart failure) to prevent or delay cardiovascular disease (CVD) in older adults with chronic kidney disease (CKD) by examining their impact on aortic stiffness in people with stage 3 CKD in a randomized, controlled study.

Key facts

Study ID

NCT00874432

Run by

University of Wisconsin, Madison

People needed

43

Starts

2009-01-01

Expected to finish

2011-12-01

Last updated by the study team

2020-10-27

Who can join

Age: 60 and older, up to 89. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age > 60 years
• BP 120/80 or higher *(bps will be checked weekly first 4 weeks to ensure < 130/80 - IF bp remains > 130/80 we will administer other bp meds per JNC VII guidelines)
• CKD stage 3 (GFR 30 - 59 ml/min) for CKD group; no CKD for control group

You may not qualify if…

• Known significant CVD (history of Myocardial infarction (MI), recurrent stroke, or New York Heart Association (NYHA) class III or greater).
• Serum potassium > 5.2 meq/L
• Known allergy or hypersensitivity to ACE inhibitor or ARB
• Female of childbearing age not practicing contraception
• Current treatment with an Angiotensin Converting Enzyme Inhibitors (ACE-I) or Angiotensin-Receptor Blockers (ARB) (Note: can participate if on ACE-I after 6 week washout period)
• History of ACE-I induced angioedema
• History of angioedema, hereditary or idiopathic
• Persons lacking consent capacity
• 500 mg/dL proteinuria on 2 consecutive spot urine protein/creat ratios

Where it is running

• University of Wisconsin-Madison Hospitals and Clinics — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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