Identifying Brain and Genetic Markers of Sertraline Treatment Response in People With Social Anxiety Disorder

Completed

Conditions studied: Anxiety Disorders

In brief

This study will attempt to identify gene and brain activity markers that predict whether people with social anxiety disorder will respond to selective serotonin reuptake inhibitor medications.

Key facts

Study ID

NCT00872131

Run by

University of Michigan

People needed

200

Starts

2008-03-01

Expected to finish

2011-08-01

Last updated by the study team

2011-11-23

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• For social anxiety disorder group:
• Current diagnosis of social anxiety disorder, generalized subtype
• Physically healthy, as confirmed by comprehensive medical history, physical exam, and laboratory testing
• For healthy control group:
• Never been diagnosed with either Axis I or Axis II mental disorders
• Physically healthy, as confirmed by comprehensive medical history, physical exam, and laboratory testing

You may not qualify if…

• Clinically significant medical or neurologic condition
• Diagnosis of primary comorbid anxiety disorder, defined by which disorder is the more debilitating and clinically salient
• History of bipolar disorder or schizophrenia
• Presence of an organic mental syndrome, mental retardation, or pervasive developmental disorder
• Current major depressive disorder or major depression within the past 6 months
• Hamilton Rating Scale for Depression score greater than 18
• Alcohol or drug abuse or dependence within the past year
• Current suicidal ideation
• Diagnosis of an Axis II personality disorder, except for avoidant personality disorder
• Treatments with psychotropic or psychoactive medications within the 2 weeks before screening (or 8 weeks for fluoxetine and 4 weeks for monoamine oxidase inhibitors)
• Positive urine drug screen results
• Pregnancy
• Additional exclusion criteria for the functional MRI studies:
• Left-handedness, as determined by standard questionnaire
• Presence of ferrous-containing metals within the body, such as aneurysm clips, shrapnel, or retained particles
• Claustrophobia

Where it is running

• University of Michigan — Ann Arbor, Michigan, United States

Full record on ClinicalTrials.gov

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