Personalized Warfarin Dosing by Genomics and Computational Intelligence

Stopped early · Not applicable

Conditions studied: Venous Thrombosis, Atrial Fibrillation, Myocardial Infarction

In brief

This study will create a computer program that can be used to help dose a drug called warfarin for the prevention of blood clotting. The study will collected specific information about those patients receiving this drug and use that information to create a computer program that will predict the effects of the drug. With this prediction program in place, the investigators can perform a series of "what if I gave this amount of drug" simulations to determine the best dose of drug for that patient. Once the computer programs are developed, the investigators will test the program in patients that actually need this drug. They will also include genetic information into the prediction since it has been shown that this information can affect how well the drug works. Patients will have this genetic information determined during this study.

Key facts

Study ID

NCT00872079

Run by

US Department of Veterans Affairs

People needed

175

Starts

2008-09-01

Expected to finish

2011-09-01

Last updated by the study team

2014-02-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Warfarin therapy
• Attend anticoagulation clinic
• Warfarin therapy for 6 months

You may not qualify if…

• History of non-compliance

Where it is running

• VA Medical Center, Louisville — Louisville, Kentucky, United States

Full record on ClinicalTrials.gov

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