Neurobiological Correlates of Post Traumatic Stress Disorder (PTSD) During Rapid Eye Movement (REM) Sleep
Completed
Conditions studied: Post-Traumatic Stress Disorder
In brief
The overarching aim of this Exploratory/Developmental Research Grant Award (R21) is to explore the neurobiological correlates of PTSD during REM sleep by using state-of-the science positron emission tomography (PET) sleep imaging. This study will allow us to gain insight into the differences in sleep and waking brain mechanisms between veterans with PTSD and those without PTSD.
Key facts
- Study ID
- NCT00871650
- Run by
- University of Pittsburgh
- People needed
- 24
- Starts
- 2009-03-01
- Expected to finish
- 2011-11-01
- Last updated by the study team
- 2013-01-16
Who can join
Age: 18 and older, up to 50. Sex: male. Healthy volunteers: accepted.
You may not qualify if…
- Trauma occurred less than 3 months prior to study entry
- CES score < 17
- Taking medications known to affect sleep and / or brain glucose metabolism
- Current diagnosis of depression as determined by the SCID or BDI score > 13
- History of psychotic or bipolar disorder
- Current history (within 3 months) of substance or alcohol abuse as determined by the SCID
- Positive alcohol blood test at screening or during the PET protocol
- Significant or unstable acute or chronic medical conditions
- Other current sleep disorders, such as insufficient sleep syndrome, delayed sleep phase syndrome, narcolepsy, restless legs syndrome, periodic leg movement disorder, obstructive sleep apnea, and current night shift work, suspected during the structured interview. Individuals who are found to have a apnea-hypopnea index (AHI) > 10 or an index of periodic leg movements with arousal > 15 will be excluded.
- Presence of implanted devices such as cardiac pacemaker, aneurysm clip, ear implant, shrapnel, neurostimulators or other metal devices
- Fear of closed spaces
- Previous radiation. Due to the risk of radiation exposure, we will exclude subjects who have had PET scans or other radiotracer exposure in the previous year.
- History of open head injury.
Where it is running
- University of Pittsburgh — Pittsburgh, Pennsylvania, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.