Airway Macrophages and Sputum Milieu in Adult Subjects With Airflow Obstruction

Completed

Conditions studied: Pulmonary Disease, Chronic Obstructive, Bronchitis, Chronic, Occupational Diseases, Tobacco Use Disorder

In brief

Airway macrophage impairment is a central feature in the immunopathogenesis of chronic obstructive pulmonary disease, regardless of smoking status.

Key facts

Study ID

NCT00871637

Run by

University of Nebraska

People needed

30

Starts

2008-08-01

Expected to finish

2009-06-01

Last updated by the study team

2023-09-07

Who can join

Age: 50 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Medically stable to participate in induced sputums
• Group One: Smoked less than 100 cigarettes in their lifetime Quit smoking greater than 10 years ago Pre-bronchodilator FEV1/FVC > 70% Pre-bronchodilator FEV1 % predicted > 80%
• Group Two: Greater than a 20-pack year tobacco history Smoked in the last two years Post-bronchodilator FEV1/FVC < 70%
• Group Three:Have less than a 20-pack year tobacco history Quit smoking greater than 20 years ago Post-bronchodilator FEV1/FVC < 70%

You may not qualify if…

• Personal history of lung cancer
• Pregnancy
• Personal history of autoimmune disease
• Currently taking oral/parental corticosteroids
• Personal history of upper or lower respiratory tract infection in the prior four weeks

Where it is running

• University of Nebraska — Omaha, Nebraska, United States

Full record on ClinicalTrials.gov

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