Pilot Study Evaluating Stress Response and Immune Function in Mechanically Ventilated Patients With Alcohol Use Disorders Treated With Propofol or Midazolam

Withdrawn before enrolling · Phase 4

Conditions studied: Alcoholism, Respiration, Artificial

In brief

The aim of this study is to evaluate the effects of the sedatives propofol and midazolam on stress response and immune function in critically ill patients with alcohol use disorders who are undergoing mechanical ventilation.

Key facts

Study ID

NCT00871039

Run by

Virginia Commonwealth University

People needed

0

Starts

2009-03-01

Expected to finish

2009-03-01

Last updated by the study team

2016-03-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of alcohol use disorders
• Need for invasive mechanical ventilation
• Need for continuous intravenous infusion of sedative(s)

You may not qualify if…

• Age < 18 years
• Pregnant women
• Prisoners
• Receiving propofol prior to randomization
• Patient experiencing active alcohol withdrawal
• Immunosuppression
• Shock
• Attending physician does not feel patient is candidate to receive either propofol or midazolam
• Patient has contraindication(s) to receiving either propofol or midazolam
• Inability to enroll patient within 96 hours after initiation of mechanical ventilation
• Transfer from another intensive care unit

Where it is running

• Virginia Commonwealth University Medical Center (formerly known as Medical College of Virginia) — Richmond, Virginia, United States
• Virginia Commonwealth University Medical Center — Richmond, Virginia, United States

Full record on ClinicalTrials.gov

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