Investigation of Lithium on Signal Transduction, Gene Expression and Brain Myo-Inositol Levels in Manic Patients

Completed · Phase 4

Conditions studied: Bipolar Disorder

In brief

This study investigates the effects of Lithium treatment on signal transduction pathways, gene expression and brain neurochemistry and structure in patients with Bipolar disorder. It is hypothesized that specific changes in these markers will correlate with lithium treatment responsiveness.

Key facts

Study ID

NCT00870311

Run by

Wayne State University

People needed

28

Starts

1996-03-01

Expected to finish

2004-04-01

Last updated by the study team

2009-03-27

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Meet diagnostic criteria for Bipolar Mood Disorder determined by DSM-IV (SCID)

You may not qualify if…

• Meeting criteria for any other DSM-IV axis I disorder
• Psychoactive substance abuse or dependence within the past 1 year
• Medical conditions placing patients at increased risk for lithium treatment (including renal disease, hepatic disease, hematological disease)
• Devices/implants or conditions which preclude MRI investigation (including cardiac pacemaker/ICD, aneurysm clips, neurostimulator device, metallic fragments in or near the eye,claustrophobia)

Where it is running

• Wayne State University School of Medicine — Detroit, Michigan, United States

Full record on ClinicalTrials.gov

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