Dominantly Inherited Alzheimer Network (DIAN)

Recruiting now

Conditions studied: Alzheimer's Disease

In brief

The purpose of this study is to identify potential biomarkers that may predict the development of Alzheimer's disease in people who carry an Alzheimer's mutation.

Key facts

Study ID

NCT00869817

Run by

Washington University School of Medicine

People needed

700

Starts

2009-01-01

Expected to finish

2026-09-01

Last updated by the study team

2026-07-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Written informed consent obtained from participant and collateral source prior to any study-related procedures.
• Aged 18 (inclusive) or older and the child of an affected individual (clinically or by testing) in a pedigree with a known mutation for ADAD.
• Cognitively normal to very mild or mild cognitive impairment (CDR score range 0-1.0). Primary enrollment will focus on the recruitment of asymptomatic adult children who are more than 15 years younger than the estimated age of symptom onset. Enrollment of new participants with moderate cognitive impairment is allowed with the prior approval of the DIAN Coordinating Center.
• Has two persons who are not their full-blooded siblings who can serve as collateral sources for the study.
• Fluent in a language approved by the DIAN Coordinating Center at about the 6th grade level (international equivalent) or above.

You may not qualify if…

• Under age 18
• Medical or psychiatric illness that would interfere in completing initial and follow-up visits
• Requires nursing home level care
• Has no one who can serve as a study informant

Where it is running

• Institute of Neurology, Queen Square — London, United Kingdom (enrolling)
• Indiana University-Indiana Alzheimer Disease Center — Indianapolis, Indiana, United States (enrolling)
• Brigham and Women's Hospital — Boston, Massachusetts, United States (enrolling)
• Washington University in St. Louis School of Medicine — St Louis, Missouri, United States (enrolling)
• Tokyo University — Tokyo, Japan (enrolling)
• Instituto Nacional de Neurología y Neurocirugía "Manuel Velasco Suarez" — Mexico City, Mexico City, Mexico (enrolling)
• Amsterdam UMC — Amsterdam, Netherlands (enrolling)
• Asan Medical Center — Seoul, Songpa-Gu, South Korea (enrolling)
• Mayo Clinic Jacksonville — Jacksonville, Florida, United States (enrolling)
• University of Pittsburgh — Pittsburgh, Pennsylvania, United States (enrolling)
• Butler Hospital — Providence, Rhode Island, United States (enrolling)
• University of Washington — Seattle, Washington, United States (enrolling)
• Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI) — Salta, Salta Province, Argentina (enrolling)
• Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia" (FLENI) Instituto de Investigaciones Neurológicas Raúl Correa — Buenos Aires, Argentina (enrolling)
• Neuroscience Research Australia — Sydney, New South Wales, Australia (enrolling)
• Sir James McCusker Alzheimer's Disease Research Unit, Edith Cowan University — Perth, Western Australia, Australia (enrolling)
• Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo — São Paulo, São Paulo, Brazil (enrolling)
• Grupo Neurociencias de Antioquia — Medellín, Colombia, Colombia (enrolling)
• German Center for Neurodegenerative Diseases (DZNE) Munich, and University Hospital Ludwig-Maximilians-Universitat (LMU) Munich — Munich, Germany (enrolling)
• German Center for Neurodegenerative Diseases (DZNE) Tübingen and Hertie-Institute for Clinical Brain Research, University of Tübingen — Tübingen, Germany (enrolling)
• Niigata University — Niigata, Japan (enrolling)
• Columbia University — New York, New York, United States
• Hospital Clinic Barcelona — Barcelona, Catalonia, Spain
• McGill University Research Centre for Studies in Aging — Verdun, Quebec, Canada
• Mental Health Research Institute, University of Melbourne — Melbourne, Victoria, Australia

Full record on ClinicalTrials.gov

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