Warfarin and Coronary Calcification Project

Completed

Conditions studied: Coronary Calcification

In brief

The purpose of the study is to assess whether the use of warfarin, a commonly used anticoagulation drug, is associated with increased amounts of coronary artery calcification. Studies in animals and preliminary but small retrospective studies in humans have suggested a possible link to increased tissue calcification with use of this drug. The researchers will investigate this by assessing the amount of calcification seen in the coronary arteries using a specialized computed tomography (CT) scan (electron-beam CT) and assessing to see if the amount is influenced by the amount of time a patient has been taking warfarin. The researchers will exclude patients with known coronary artery disease, chronic kidney disease or hyperparathyroidism.

Key facts

Study ID

NCT00868712

Run by

Walter Reed Army Medical Center

People needed

70

Starts

2004-05-01

Expected to finish

2010-01-01

Last updated by the study team

2012-08-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18 years of age or older
• Patients referred to begin or already treated with warfarin anticoagulation therapy.

You may not qualify if…

• Known prior myocardial infarction or coronary heart disease
• History of advanced chronic kidney disease manifested by serum creatinine>2 or calculated glomerular filtration rate (GFR)<30
• History of hyperparathyroidism
• Current hypercalcemia
• Current hyperphosphatemia
• Uncertain duration of warfarin therapy
• Lack of records documenting international normalized ratio (INR) during therapy

Where it is running

• Walter Reed Army Medical Center — Washington D.C., District of Columbia, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.