Evaluating for Contact Allergies in Patients With Chronic Urticaria

Completed

Conditions studied: Urticaria, Patch Testing, Dermatitis, Allergy, Contact Sensitization

In brief

Hives affects 10-25% of the population worldwide at some time during their lifetime. Hives are itchy transient swellings of the skin lasting 4-36 hours. Chronic urticaria is defined as hives that have been ongoing for six weeks or more. Patch testing is performed to diagnose allergic contact dermatitis, and if contact allergens are found via patch testing, patients can often be cured of their dermatitis. However, patch testing is currently not routinely performed in the evaluation of patients with chronic idiopathic urticaria. Our hypothesis is to see if contact allergens can be identified with patch testing in patients with chronic urticaria, and, if any allergens are identified, to see if avoiding these contact allergens will make the chronic urticaria go away.

Key facts

Study ID

NCT00868036

Run by

Tufts Medical Center

People needed

23

Starts

2008-12-01

Expected to finish

2011-01-01

Last updated by the study team

2019-09-11

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients must have a documented diagnosis of chronic urticaria, which is defined as:
• urticaria (hives), in which each individual lesion lasts less than 48 hours,
• urticaria which occurs several times per week,
• urticaria which has lasted in this manner for a minimum of 6 weeks.
• Referring physicians will be asked to provide this documentation, and patients will be asked to confirm these characteristics. Patients should have already undergone a workup to exclude other causes of their urticaria, and if any abnormalities have been encountered, these abnormalities would need to be insufficient to explain the extent of their urticaria.

You may not qualify if…

• Those patients with an explanation for their chronic urticaria.
• Patients may have their test postponed if they are currently using topical steroids to the area to be tested, or are taking prednisone or its equivalent daily.
• Due to PI moving locations, no additional information available.

Where it is running

• Tufts Medical Center, Department of Dermatology — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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