Bevacizumab and Sorafenib as First-Line Therapy in Treating Patients With Locally Advanced or Metastatic Liver Cancer

Completed · Phase 1/Phase 2

Conditions studied: Liver Cancer

In brief

RATIONALE: Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Sorafenib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Bevacizumab and sorafenib may also stop the growth of liver cancer by blocking blood flow to the tumor. PURPOSE: This randomized phase I/II trial is studying the best dose of bevacizumab when given together with sorafenib as first-line therapy in treating patients with locally advanced or metastatic liver cancer.(Phase I closed to accrual as of 11/03/2010)

Key facts

Study ID

NCT00867321

Run by

Alliance for Clinical Trials in Oncology

People needed

24

Starts

2009-04-01

Expected to finish

2013-05-01

Last updated by the study team

2022-04-19

Who can join

Age: 18 and older, up to 120. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Genesys Hurley Cancer Institute — Flint, Michigan, United States
• Hurley Medical Center — Flint, Michigan, United States
• Butterworth Hospital at Spectrum Health — Grand Rapids, Michigan, United States
• CCOP - Grand Rapids — Grand Rapids, Michigan, United States
• Lacks Cancer Center at Saint Mary's Health Care — Grand Rapids, Michigan, United States
• Van Elslander Cancer Center at St. John Hospital and Medical Center — Grosse Pointe Woods, Michigan, United States
• Dickinson County Healthcare System — Iron Mountain, Michigan, United States
• Foote Memorial Hospital — Jackson, Michigan, United States
• Sparrow Regional Cancer Center — Lansing, Michigan, United States
• St. Mary Mercy Hospital — Livonia, Michigan, United States
• Mercy General Health Partners — Muskegon, Michigan, United States
• St. Joseph Mercy Oakland — Pontiac, Michigan, United States
• Mercy Regional Cancer Center at Mercy Hospital — Port Huron, Michigan, United States
• Seton Cancer Institute at Saint Mary's - Saginaw — Saginaw, Michigan, United States
• Munson Medical Center — Traverse City, Michigan, United States
• St. John Macomb Hospital — Warren, Michigan, United States
• Metro Health Hospital — Wyoming, Michigan, United States
• MeritCare Bemidji — Bemidji, Minnesota, United States
• Fairview Ridges Hospital — Burnsville, Minnesota, United States
• Mercy and Unity Cancer Center at Mercy Hospital — Coon Rapids, Minnesota, United States
• Duluth Clinic Cancer Center - Duluth — Duluth, Minnesota, United States
• CCOP - Duluth — Duluth, Minnesota, United States
• Miller - Dwan Medical Center — Duluth, Minnesota, United States
• Fairview Southdale Hospital — Edina, Minnesota, United States
• Green Bay Oncology, Limited - Escanaba — Escanaba, Michigan, United States

Full record on ClinicalTrials.gov

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