DHA Supplements to Improve Insulin Sensitivity in Obese Pregnant Women (The Omega-3 Pregnancy Study)
Status unconfirmed · Phase 1 · Has a placebo group
Conditions studied: Overweight and Obesity, Insulin Resistance, Diabetes, Gestational, Hypertension in Pregnancy, Pre-Eclampsia
In brief
Women with excess adiposity while pregnant are more likely to develop gestational diabetes and high blood pressure during pregnancy than women of healthy weights. This may occur because overweight and obese pregnant women are less sensitive to insulin and have more inflammation than pregnant women of healthy weights. This study will examine the effect of a nutritional supplement, docosahexaenoic acid (DHA), on improving insulin sensitivity and lessening inflammation in overweight and obese pregnant women.
Key facts
- Study ID
- NCT00865683
- Run by
- National Heart, Lung, and Blood Institute (NHLBI)
- People needed
- 90
- Starts
- 2009-04-01
- Expected to finish
- 2011-07-01
- Last updated by the study team
- 2009-07-15
Who can join
Age: 18 and older, up to 40. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- Pre-pregnant body mass index greater than 25
- Singleton pregnancy
- Speaks English
You may not qualify if…
- High intake of DHA foods (i.e., more than 1 fish meal per week, use of DHA-fortified foods, or use of any supplements that contain DHA)
- Concurrent inflammatory, vascular, or metabolic disease, including diabetes, polycystic ovary disease, collagen vascular disease, inflammatory bowel disease, or infection
- Current or previous use of tobacco, street drugs, or medications known to affect inflammatory markers, including corticosteroids
- Excessive weight gain or loss before pregnancy (more than 20 pounds), including weight loss due to bariatric surgery
- Plans to leave the area during the study period
- Inability to travel to General Clinical Research Center
Where it is running
- General Clinical Research Center — Cincinnati, Ohio, United States (enrolling)
Full record on ClinicalTrials.gov
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