Pharmacotoxicology of Trichloroethylene Metabolites

Stopped early · Not applicable

Conditions studied: Healthy

In brief

This project focuses on the kinetics, metabolism and human toxicology of dichloroacetate (DCA)and tyrosine catabolism. The hypothesis is that tyrosine metabolism will be greatest in subject who harbor the KRT variant for GSTz1/MAAI for which DCA exhibits a high Km.

Key facts

Study ID

NCT00865514

Run by

University of Florida

People needed

2

Starts

2011-08-01

Expected to finish

2012-01-01

Last updated by the study team

2015-06-03

Who can join

Age: 22 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adults scheduled for elective surgery for benign liver disease.
• Normal EKG and history
• Normal baseline labs

You may not qualify if…

• Pregnancy
• severe anemia, defined as a hematocrit < 30%.
• diabetes mellitus
• renal insufficiency, defined as a serum creatinine > 1.5 mg/dl or a creatinine clearance < 60 ml/min
• elevated liver enzymes
• psychiatric illness requiring medication
• primary biliary cirrhosis or any other form of cirrhosis
• viral hepatitis or non-viral steatohepatitis
• coronary heart disease, defined as requiring daily administration of anti-anginal drugs or as New York Heart Association Class III or IV heart failure
• malignancy of any type in any anatomical location

Where it is running

• University of Florida — Gainesville, Florida, United States

Full record on ClinicalTrials.gov

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