Impact of Pulsatile Cardio-Pulmonary Bypass (CPB) on Vital Organ Recovery

Running, not enrolling

Conditions studied: Cardio-Pulmonary Bypass

In brief

This research study is about the effect heart-lung bypass procedures have on the vital organs (brain, heart, lungs, and kidneys) during open-heart surgery in pediatric patients. There are two types of heart pumps used in surgery requiring heart-lung bypass; one pumps the blood continuously through the body and the other pumps the blood with repeated pulses. Both pumps are approved for clinical use by the FDA. Although 90% of institutions still use non-pulsatile flow, some studies show there may be benefits to using pulsatile flow during surgery. The investigators want to learn whether the vital organs (brain, heart, lungs, and kidneys) respond differently to one method than they do to the other. Approximately 300 children will take part in this research at the Hershey Medical Center.

Key facts

Study ID

NCT00862407

Run by

Milton S. Hershey Medical Center

People needed

300

Starts

2008-10-01

Expected to finish

2030-12-31

Last updated by the study team

2026-04-08

Who can join

Age: 0 and older, up to 17. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients recruited from Penn State Children's Hospital undergoing cardiac surgery with cardiopulmonary bypass.

You may not qualify if…

• Patients older than 17 years will be excluded.

Where it is running

• Penn State College of Medicine — Hershey, Pennsylvania, United States

Full record on ClinicalTrials.gov

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